Join the M-Boltz Hackathon with Merck KGaA, Darmstadt, Germany and the Boltz team from Oct. 20th to 21st to help shape the future of biochemical co-folding models. 

Boltz is a fully open-source co-folding model predicting 3D structure of proteins, nucleic acids, drugs, and more. It is revolutionizing the field as a foundation model for drug discovery, covering both structure and affinity predictions. Boltz democratizes state-of-the-art co-folding technology, providing cutting-edge technology to students, academics, and industry experts.

The Boltz team and Merck KGaA, Darmstadt, Germany are joining forces in organizing focused challenges for improving the Boltz model and associated workflows.

The hackathon will cover the following topics:

• Improving Boltz predictions with one challenge focusing on antibody-antigen complexes and another one on allosteric small-molecule binders. An independent evaluation will be performed on an internal dataset provided by Merck KGaA, Darmstadt, Germany.

• Improving computational scalability of Boltz2 model as a dedicated challenge.

• Open-ended contributions to code base or curated datasets for model training and evaluation.

 

Most importantly, we want to make sure that the developments will benefit the community by:

• Publishing a leaderboard, including performance evaluation on internal data of Merck KGaA, Darmstadt, Germany. 

• Collecting and sharing all contributions within a GitHub repository of the hackathon.

WHERE: Two in-person hubs in Darmstadt (DE) and Boston (MA, USA), plus remote participation. 

WHEN: Monday, Oct. 20 to Tuesday, Oct. 21, 2025 (Darmstadt: starting on 20th at 3pm and ending on 21st at 6pm CEST | Boston: starting on 20th at 9am and ending on 21st at 12pm EDT) 

SPONSORED BY: AWS, NVIDIA, and Hugging Face

SUPPORTED BY: MIT Jameel Clinic

Ready to build with us? ​​